- Studies on the molecular mechanisms by which toxic agents (chemical and biological) interact with living systems. "Toxic agent" is broadly defined as any molecule or aggregate of molecules that causes cellular damage. "Interactions" are broadly defined to include metabolism, chemical alteration of cellular constituents, adduct formation with cellular constituents, and specific or nonspecific interactions with cellular receptors or enzymes, leading to activation or inactivation.
- Studies of the molecular mechanisms of the cellular responses to toxic agents. These may include, but are not necessarily limited to, alterations in global cellular constituents (DNA, proteins, lipids, carbohydrates), repair of damaged cellular constituents, alterations in gene transcription/translation, induction of genetic mutations, activation/ inactivation of stress responses, cell cycle arrest, apoptosis, or necrosis.
- Studies of the mechanisms by which the cellular responses to toxic agents affect the intact organism, leading to the pathogenesis of disease.
- Studies of the development and application of new methodologies for the investigation of the interaction of toxic agents with living systems.
In the case of uncertainty regarding the suitability of a manuscript, authors may send an abstract to the Editor by e-mail (firstname.lastname@example.org) to request an opinion prior to submission.
For more information about submission: